Dasatinib and PD-L1 inhibitors provoke toxicity and inhibit angiogenesis in the embryo
نویسندگان
چکیده
Dasatinib is a targeted cancer therapy, while programmed death ligand 1 (PD-L1) inhibitors are form of immune checkpoint therapy used to treat various types cancers. Several studies showed the potential efficacy these drugs in management triple-negative breast cancer- an aggressive subtype cancer, which can develop during pregnancy. Nevertheless, side effects (DA) and PD-L1 pregnancy, especially early stages embryogenesis not explored yet. The aim this study assess individual combined toxicity DA evaluate their effect(s) on angiogenesis using chorioallantoic membrane (CAM) model embryo. Our results show that embryos die at greater rates after exposure as compared matched controls. Moreover, treatment with significantly inhibits CAM. To further elucidate key regulator genes embryotoxicity induced by actions DA, RT-PCR analysis was performed for seven target regulate cell proliferation, angiogenesis, survival (ATF3, FOXA2, MAPRE2, RIPK1, INHBA, SERPINA4, VEGFC). data revealed deregulated brain, heart, liver tissues exposed embryos, control tissues. necessary anti role
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ژورنال
عنوان ژورنال: Biomedicine & Pharmacotherapy
سال: 2021
ISSN: ['0753-3322', '1950-6007']
DOI: https://doi.org/10.1016/j.biopha.2020.111134